- 職位
- 教授
- 学位・資格
- 医学博士
- 専門領域・分野
- 神経科学、脳科学、生理学
- 担当科目
- 基礎生物学、人体の構造と機能Ⅱ、基礎医学実習、専門ゼミⅠ・Ⅱ・Ⅲ・Ⅳ、卒業研究
略歴
1983年東京大学理学部生物学科卒、1985年大阪大学大学院医学研究科医科学専攻修士課程修了、1989年同研究科神経生理学専攻博士課程修了(医学博士)。1989年大阪大学医学部附属バイオメディカル教育研究センター助手、1999年同センター助教授、2001年大阪大学大学院医学系研究科助教授、2007年同大学院准教授。2021年より本学教授。
社会活動等
日本生理学会評議員
著書等
- 「プログレッシブ生命科学」(共著)南山堂,東京,208-213,2014.
- 「ブレイン・サイエンスレビュー2006」(共著)クバプロ,東京,79-104,2006.
- 「Slow synaptic responses and modulation」(共著)Springer,Tokyo,Japan,297-306,2000.
- 「脳を知る」(共著)秀潤社,59-63,1999.
- 「Excitatory Amino Acids and the Cerebral Cortex」(共著)MIT Press, Cambridge, USA,147-153,1996.
- 「Excitatory Amino Acid and Neural Plasticity」(共著)Springer, Boston, MA,173-180,1990.
- 「Brain Signal Transduction and Memory」(共著)Academic Press,241-255,1989.
- 「Frontiers in Excitatory Amino Acid Research」(共著)Alan R. Liss, Inc. New York,435-442,1988.
- 「Neurotransmitters: Focus on excitatory amino acids」(共著)Elsevier Science Ltd. Amsterdam,80-91,1988.
主な研究実績
- Kimura F, Itami C:A hypothtical model concerning how spike timing-dependent plasticity contributes to neural circuit formation and initiation of the critical period in barrel cortex.The Journal of Neuroscience 39:3784-3791,2019.
- Ohshima M, Itami C, Kimura F:The α2A‐adrenoceptor suppresses excitatory synaptic transmission to both excitatory and inhibitory neurons in layer 4 barrel cortex.The Journal of Physiology (London) 595(22):6923-6937,2017.
- Itami C, Kimura F:Concurrently-induced plasticity due to convergence of distinct forms of spike timing-dependent plasticity in the developing barrel cortex.European Journal of Neuroscience 44(12):2984-2990,2016.
- Itami C, Huang J-Y, Yamasaki M, Watanabe M, Lu H-C, Kimura F:Developmental switch in spike-timing dependent plasticity and cannabinoid-dependent reorganization of the thalamocortical projection in the barrel cortex.Journal of Neuroscience 36(26):7039-7054,2016.
- Malyshavskaya O, Shiraishi Y, Kimura F, Yamamoto N:Role of electrical activity in horizontal axon growth in the developing cortex: a time-lapse study using optogenetic stimulation.PLoS One 8(12):e82954,2013.
- Itami C, Kimura F:Developmental switch in spike timing-dependent plasticity at layers 4-2/3 in the rodent barrel cortex.Journal of Neuroscience 32(43):15000-15011,2012.
- Ikezoe K, Tamura H, Kimura F, Fujuta I:Decorrelation of sensory-evoked neuronal responses in rat barrel cortex during postonatal development.Neuroscience Research 73(4):312-320,2012.
- Kimura F, Itami C, Ikezoe K, Tamura H, Fujita I, Yanagawa Y, Obata K, Ohshima M:Fast activation of feedforward inhibitory neurons from thalamic input and its relevance to the regulation of spike sequences in the barrel cortex.Journal of Physiology (London) 588:2769-2787,2010.
- Akaneya Y, Souya K, Kitamura A, Kimura F, Washburn C, Zhou R, Ninan I, Tsumoto T, Ziff E:Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development.PLoS One 5(8):e12486,2010.
- Itami C, Kimura F, Nakamura S:Brain-derived neurotrophic factor regulates the maturation of layer 4 fast spiking cells after the 2nd postnatal week in the developing barrel cortex.Journal of Neuroscience 27:2241-2252,2007.
- Yanagisawa T, Tsumoto T, Kimura,F:Transiently higher release probability during critical period at thalamocortical synapses in the mouse barrel cortex: Relevance to differential short-term plasticity of AMPA- and NMDA-EPSCs and possible involvement of silent synapses.European Journal of Neuroscience 20: 3006-3018,2004.
- Palizvan M.R, Sohya K, Kohara K, Maruyama A, Yasuda H, Kimura F, Tsumoto T:Brain-Derived Neurotrophic Factor increases inhibitory synapses revealed in solitary neurons cultured from rat visual cortex.Neuroscience 126:955-966,2004.
- Kimura F, Fukuda M, Tsumoto T:Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex.Journal of Physiology (London) 524:195-20,2000.
- Kimura F, Fukuda M, Tsumoto T:Acetylcholine suppresses the spread of excitation in the visual cortex revealed by optical recording: Possible differential effect depending on the source of input.European Journal of Neuroscience 11(10):3597-3609,1999.
- Yoshimura Y, Kimura F, Tsumoto T:Estimation of single channel conductance underlying synaptic transmission between pyramidal cells in the visual cortex.Neuroscience 88(2):347-352,1999.
- Kimura F, Baughman R.W:GABAergic transcallosal neurons in developing rat neocortex.European Journal of Neuroscience 9(6):1137-1143,1998.
- Kimura F, Otsu Y, Tsumoto T:Presynaptically "Silent" Synapses: Spontaneously Active Terminals without Stimulus-Evoked Release Demonstrated in Cortical Autapses.Journal of Neurophysiology 77(5):2805-2815,1997.
- Kimura F, Baughman R.W:Distinct muscarinic receptor subtypes suppress excitatory and inhibitory synaptic responses in cortical neurons.Journal of Neurophysiology 77(2):709-71,1997.
- Otsu Y, Kimura F, Tsumoto T:Hebbian induction of LTP in visual cortex: Perforated study in cultured neurons.Journal of Neurophysiology 74(6):2437-2444,1995.