職位

教授

学位・資格

医学博士

専門領域・分野

神経科学、脳科学、生理学

担当科目

基礎生物学、人体の構造と機能Ⅱ、基礎医学実習、専門ゼミⅠ・Ⅱ・Ⅲ・Ⅳ、卒業研究

略歴

1983年東京大学理学部生物学科卒、1985年大阪大学大学院医学研究科医科学専攻修士課程修了、1989年同研究科神経生理学専攻博士課程修了（医学博士）。1989年大阪大学医学部附属バイオメディカル教育研究センター助手、1999年同センター助教授、2001年大阪大学大学院医学系研究科助教授、2007年同大学院准教授。2021年より本学教授。

社会活動等

日本生理学会評議員

著書等

• 「プログレッシブ生命科学」（共著）南山堂，東京，208-213，2014．
• 「ブレイン・サイエンスレビュー2006」（共著）クバプロ，東京，79-104，2006．
• 「Slow synaptic responses and modulation」（共著）Springer，Tokyo，Japan，297-306，2000．
• 「脳を知る」（共著）秀潤社，59-63，1999．
• 「Excitatory Amino Acids and the Cerebral Cortex」（共著）MIT Press, Cambridge, USA，147-153，1996．
• 「Excitatory Amino Acid and Neural Plasticity」（共著）Springer, Boston, MA，173-180，1990．
• 「Brain Signal Transduction and Memory」（共著）Academic Press，241-255，1989．
• 「Frontiers in Excitatory Amino Acid Research」（共著）Alan R. Liss, Inc. New York，435-442，1988．
• 「Neurotransmitters: Focus on excitatory amino acids」（共著）Elsevier Science Ltd. Amsterdam，80-91，1988．

主な研究実績

• Kimura F, Itami C：A hypothtical model concerning how spike timing-dependent plasticity contributes to neural circuit formation and initiation of the critical period in barrel cortex．The Journal of Neuroscience 39：3784-3791，2019．
• Ohshima M, Itami C, Kimura F：The α2A‐adrenoceptor suppresses excitatory synaptic transmission to both excitatory and inhibitory neurons in layer 4 barrel cortex．The Journal of Physiology (London) 595(22)：6923-6937，2017．
• Itami C, Kimura F：Concurrently-induced plasticity due to convergence of distinct forms of spike timing-dependent plasticity in the developing barrel cortex．European Journal of Neuroscience 44(12)：2984-2990，2016．
• Itami C, Huang J-Y, Yamasaki M, Watanabe M, Lu H-C, Kimura F：Developmental switch in spike-timing dependent plasticity and cannabinoid-dependent reorganization of the thalamocortical projection in the barrel cortex．Journal of Neuroscience 36(26)：7039-7054，2016．
• Malyshavskaya O, Shiraishi Y, Kimura F, Yamamoto N：Role of electrical activity in horizontal axon growth in the developing cortex: a time-lapse study using optogenetic stimulation．PLoS One 8(12)：e82954，2013．
• Itami C, Kimura F：Developmental switch in spike timing-dependent plasticity at layers 4-2/3 in the rodent barrel cortex．Journal of Neuroscience 32(43)：15000-15011，2012．
• Ikezoe K, Tamura H, Kimura F, Fujuta I：Decorrelation of sensory-evoked neuronal responses in rat barrel cortex during postonatal development．Neuroscience Research 73(4)：312-320，2012．
• Kimura F, Itami C, Ikezoe K, Tamura H, Fujita I, Yanagawa Y, Obata K, Ohshima M：Fast activation of feedforward inhibitory neurons from thalamic input and its relevance to the regulation of spike sequences in the barrel cortex．Journal of Physiology (London) 588：2769-2787，2010．
• Akaneya Y, Souya K, Kitamura A, Kimura F, Washburn C, Zhou R, Ninan I, Tsumoto T, Ziff E：Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development．PLoS One 5(8)：e12486，2010．
• Itami C, Kimura F, Nakamura S：Brain-derived neurotrophic factor regulates the maturation of layer 4 fast spiking cells after the 2nd postnatal week in the developing barrel cortex．Journal of Neuroscience 27：2241-2252，2007．
• Yanagisawa T, Tsumoto T, Kimura,F：Transiently higher release probability during critical period at thalamocortical synapses in the mouse barrel cortex: Relevance to differential short-term plasticity of AMPA- and NMDA-EPSCs and possible involvement of silent synapses．European Journal of Neuroscience 20： 3006-3018，2004．
• Palizvan M.R, Sohya K, Kohara K, Maruyama A, Yasuda H, Kimura F, Tsumoto T：Brain-Derived Neurotrophic Factor increases inhibitory synapses revealed in solitary neurons cultured from rat visual cortex．Neuroscience 126：955-966，2004．
• Kimura F, Fukuda M, Tsumoto T：Brain-derived neurotrophic factor blocks long-term depression in solitary neurones cultured from rat visual cortex．Journal of Physiology (London) 524：195-20，2000．
• Kimura F, Fukuda M, Tsumoto T：Acetylcholine suppresses the spread of excitation in the visual cortex revealed by optical recording: Possible differential effect depending on the source of input．European Journal of Neuroscience 11(10)：3597-3609，1999．
• Yoshimura Y, Kimura F, Tsumoto T：Estimation of single channel conductance underlying synaptic transmission between pyramidal cells in the visual cortex．Neuroscience 88(2)：347-352，1999．
• Kimura F, Baughman R.W：GABAergic transcallosal neurons in developing rat neocortex．European Journal of Neuroscience 9(6)：1137-1143，1998．
• Kimura F, Otsu Y, Tsumoto T：Presynaptically "Silent" Synapses: Spontaneously Active Terminals without Stimulus-Evoked Release Demonstrated in Cortical Autapses．Journal of Neurophysiology 77(5)：2805-2815，1997．
• Kimura F, Baughman R.W：Distinct muscarinic receptor subtypes suppress excitatory and inhibitory synaptic responses in cortical neurons．Journal of Neurophysiology 77(2)：709-71，1997．
• Otsu Y, Kimura F, Tsumoto T：Hebbian induction of LTP in visual cortex: Perforated study in cultured neurons．Journal of Neurophysiology 74(6)：2437-2444，1995．

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